Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 4, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Microcirculatory dysfunction in sepsis.

David J Lundy1, Stephen Trzeciak

  • 1Department of Surgery, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, NJ 08103, USA. lundy-david@cooperhealth.edu

Critical Care Nursing Clinics of North America
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microwell encapsulation scaffolds enable sustained paracrine cell therapy in limb ischaemia.

Biomaterials advances·2026
Same author

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Investigating the roles of macrophage age and circulating extracellular vesicles in cytoprotection of hypoxic renal tubular cell stress.

BMC molecular and cell biology·2026
Same author

Patient Experience of Clinician Compassion Is Associated With Healthcare System Distrust Among Emergency Department Patients.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

An Exploratory Study of Kinase Activation Profiles in Hypoxic Human Cardiomyocytes Treated with Protective Extracellular Vesicles.

Research square·2026
Same author

Machine Learning to Identify Physician Actions Associated with Patient Experience of Compassion.

Journal of general internal medicine·2025
Same journal

A New Era of Nursing Innovation.

Critical care nursing clinics of North America·2026
Same journal

Advancing Outcomes Through Innovation.

Critical care nursing clinics of North America·2026
Same journal

The Arc of Nurse Anesthesia: From Battlefield Origins to Future Innovation.

Critical care nursing clinics of North America·2026
Same journal

A Sepsis-Informed Model of Accelerated Aging.

Critical care nursing clinics of North America·2026
Same journal

TeleCritical Care Reimagined: Efficiency Through Digital Communication Application.

Critical care nursing clinics of North America·2026
Same journal

Impacts and Outcomes of Intensive Care Unit Design.

Critical care nursing clinics of North America·2026
See all related articles

Septic shock diagnosis traditionally focuses on global hemodynamics. However, microcirculatory dysfunction is key, and new microscopy techniques allow its assessment, opening doors for novel sepsis therapies.

Area of Science:

  • Critical care medicine
  • Hemodynamics
  • Microcirculation research

Background:

  • Septic shock is a leading cause of mortality.
  • Traditional management relies on global hemodynamic indices.
  • Microcirculatory dysfunction plays a critical role in septic shock pathophysiology.

Purpose of the Study:

  • To highlight the importance of microcirculatory dysfunction in septic shock.
  • To introduce in vivo video microscopy as a tool for assessing microcirculation.
  • To propose microcirculation as a target for novel sepsis therapies.

Main Methods:

  • Utilizes in vivo video microscopy.
  • Assesses microcirculatory function in human subjects.
  • Focuses on direct visualization of the microvasculature.

Related Experiment Videos

Last Updated: Jun 4, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Main Results:

  • Microcirculatory dysfunction is a critical component of septic shock.
  • In vivo video microscopy enables direct assessment of human microcirculation.
  • This technology provides new insights into disease pathophysiology.

Conclusions:

  • Microcirculatory assessment is crucial for understanding septic shock.
  • Novel therapeutic strategies targeting the microcirculation are warranted.
  • Microcirculation represents a promising frontier for sepsis treatment.