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Updated: Jan 27, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
Published on: June 6, 2020
Immunohistochemical detection and quantitation of cell surface receptors for prostanoids
1Department of Medicine/GI, University of Virginia Health System, Charlottesville, VA.
Abstract:
The mucosa of the colon occupies 25% of the intestinal wall, from the muscularis mucosa to the lumen-lining epithelium, and contains a variety of cell types, predominantly B and T lymphocytes, but also monocytes, mast cells, and macrophages (1,2). These cells secrete a variety of cytokines, including interleukins, leakotrienes, and prostaglandins. Most of these are locally active, diffuse throughout the mucosa, and do not substantially contribute to the concentration of cytokines in the blood.
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