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Updated: Jun 4, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

No access surgery: the gamma knife.

L D Lunsford1, D Kondziolka, J C Flickinger

  • 1Professor and Vice Chairman, Dept. of Neurosurgery, Professor of Radiology, Professor of Radiation Oncology, Departments of Neurological Surgery, Radiology, and Radiation Oncology, University of Pittsburgh School of Medicine, and The Specialized Neurosurgical Center, University of Pittsburgh Medical Center, Pittsburgh, PA.

Surgical Technology International
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

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Stereotactic radiosurgery, pioneered by Lars Leksell, offers a less invasive approach for treating deep brain targets. This technique, utilizing the Gamma Knife, has treated over 20,000 patients, aiming for target obliteration with reduced patient risk.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Lars Leksell developed stereotactic radiosurgery to address limitations of invasive neurosurgical procedures.
  • The Gamma Knife, a multi-source Cobalt 60 unit, was a key innovation in this field.
  • Traditional neurosurgery carried significant risks and morbidity for patients.

Purpose of the Study:

  • To introduce stereotactic radiosurgery as a less invasive treatment option.
  • To highlight the development and application of the Gamma Knife technology.
  • To reduce patient risk associated with deep intracranial target treatments.

Main Methods:

  • Development of stereotactic techniques for precise targeting.
  • Utilization of the Cobalt 60 Gamma Knife for focused radiation delivery.

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  • Single fraction, closed skull irradiation of deep intracranial targets.

    • Main Results:

    • Over 20,000 patients treated worldwide between 1967 and 1994.
    • Demonstrated feasibility of non-invasive treatment for deep brain lesions.
    • Established radiosurgery as a viable alternative to open surgery.

    Conclusions:

    • Stereotactic radiosurgery provides a minimally invasive method for treating intracranial targets.
    • The Gamma Knife enabled widespread clinical application of this technique.
    • Radiosurgery aims to achieve therapeutic goals while minimizing patient morbidity.