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[Analysis of the familial risk factors on lung cancer]
Yongtang Jin1, Xingzhou He, Xiaotie Zhou
1Department of Environmental Health, Anhui Medical University, Hefei, Anhui 230032, P.R.China.
Background:
To study the familial risk factors on lung cancer and the effect of genetic factors on lung cancer.
Methods:
With methods of genetic epidemiology, 370 probands of lung cancer and 370 spouses of the probands (control) were studied.
Results:
The risk of the probands' relatives was 1.85 times higher than that of their spouses' relatives (P < 0.01). Compared with the spouses' parents and female relatives, the OR of the probands' parents and female relatives was 2.66 and 2.64 (P < 0.01), respectively. Compard with the female controls' parents, the OR of female probands' parents was 2.27 (P < 0.01).
Conclusions:
The susceptibility of the probands' relatives with lung cancer is higher than that of their spouses' relatives. The genetic factor is one of risk factors on lung cancer.
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