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Updated: Jun 4, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Purinergic signaling in neural development.

Herbert Zimmermann¹

¹Institute of Cell Biology and Neuroscience, Biocenter, Goethe-University, Frankfurt am Main, Germany. h.zimmermann@bio.uni-frankfurt.de

Seminars in Cell & Developmental Biology

|February 16, 2011

Summary

Extracellular purine and pyrimidine compounds, known as purinergic signaling, play a crucial role in neural development. This signaling influences key processes like cell proliferation, differentiation, and survival in both embryonic and adult neurogenesis.

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Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Extracellular purines and pyrimidines are signaling molecules.
These compounds activate cellular pathways with trophic functions.
They interact with growth factors and extracellular matrix.

Purpose of the Study:

To review the role of purinergic signaling in neural development.
To highlight recent findings on purinergic signaling in neurogenesis.

Main Methods:

Literature review of studies on purinergic signaling.
Analysis of purinergic signaling's impact on neural progenitor cells.
Examination of purinergic signaling in neuronal and glial development.

Main Results:

Purinergic signaling influences progenitor cell proliferation and migration.
It is involved in neuronal and glial maturation and differentiation.
Purinergic signaling affects cell death and survival pathways.

Conclusions:

Purinergic signaling is integral to embryonic and adult neurogenesis.
Recent evidence strongly supports its contribution to neural development.