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Updated: Jun 4, 2026

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Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Diffuse anterior retinoblastoma with undetectable retinal involvement
Vikas Khetan1, Sudhir Sudrik, Shalini Singh
1Department of Ocular Oncology and Vitreoretina, Sankara Nethralaya, Chennai, India. drkhetan@yahoo.com
Journal of Pediatric Ophthalmology and Strabismus
|February 18, 2011
Summary
This case study presents diffuse anterior retinoblastoma originating from the ciliary body, with no retinal involvement. This finding questions the typical cell origin of retinoblastoma, leading to enucleation for treatment.
Area of Science:
- Ophthalmology
- Oncology
- Cell Biology
Background:
- Retinoblastoma is the most common primary intraocular malignancy in children.
- The presumed cell of origin for retinoblastoma is the developing retinal neuroepithelium.
- Anteriorly located retinoblastoma, especially with ciliary body involvement, is rare.
Related Concept Videos
The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
