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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug
Hui-Yun Wen1, Hai-Qing Dong, Wen-juan Xie
1The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China.
Chemical Communications (Cambridge, England)
|February 18, 2011
Abstract:
The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a redox-sensitive disulfide linkage.
