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Updated: Jun 4, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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Laser-induced thermal bubbles for microfluidic applications.

Kai Zhang1, Aoqun Jian, Xuming Zhang

  • 1Department of Applied Physics and Materials Research Center, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.

Lab on a Chip
|February 19, 2011
PubMed
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This summary is machine-generated.

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This study introduces a novel laser-induced thermal bubble method for precise microfluidic control. This technique enables the creation of micro-valves and pumps, enhancing lab-on-a-chip functionality.

Area of Science:

  • Microfluidics
  • Optics
  • Materials Science

Background:

  • Microfluidic devices require precise control over fluid manipulation.
  • Existing methods for generating micro-scale bubbles can be complex or limited in location control.

Purpose of the Study:

  • To develop a novel technique for generating controllable thermal bubbles in microfluidic chips.
  • To demonstrate the application of laser-induced thermal bubbles for creating microfluidic components like valves and pumps.

Main Methods:

  • Utilized continuous-wave laser-induced heat to generate thermal bubbles.
  • Employed chromium pads of varying geometries immersed in different fluids within microfluidic channels.
  • Investigated bubble generation at specific locations within microchannels.

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Last Updated: Jun 4, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

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Main Results:

  • Achieved efficient generation of thermal bubbles with controllable sizes.
  • Demonstrated effective blocking of microfluidic channels (500 × 40 μm(2) cross-section).
  • Successfully implemented direct fluid pumping at flow rates of 7.2-28.8 μl h(-1) with selectable direction.

Conclusions:

  • Laser-induced thermal bubbles offer a versatile method for microfluidic control.
  • The technique allows for bubble generation at any desired location, enabling precise manipulation.
  • This method is readily integrable into lab-on-a-chip systems to enhance functionality.