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Updated: Jun 4, 2026
09:12
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
Published on: December 20, 2019
Splicing factor SC35 promotes tau expression through stabilization of its mRNA
Wei Qian1, Khalid Iqbal, Inge Grundke-Iqbal
1Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, PR China.
FEBS Letters
|February 22, 2011
Summary
Splicing factor SC35 enhances tau expression by stabilizing tau mRNA, specifically for exon 10-containing isoforms. This discovery offers new insights into the molecular mechanisms underlying tauopathies.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Altered alternative splicing and tau accumulation are hallmarks of tauopathies.
- These molecular changes are implicated in the progression of neurodegenerative diseases.
Purpose of the Study:
- To investigate the role of splicing factor SC35 in regulating tau expression.
- To elucidate the molecular mechanisms by which SC35 influences tau isoforms.
Main Methods:
- Utilized HEK-293T cells for experimental analysis.
- Investigated the effects of SC35 on tau transcription and mRNA stability.
- Examined SC35 binding to specific elements within tau exon 10.
Main Results:
- SC35 promotes tau exon 10 inclusion and enhances overall tau expression.
- SC35's effect is specific to tau isoforms containing exon 10.
- SC35 stabilizes tau mRNA by binding to an exon 10 element, without altering transcription.
Conclusions:
- SC35 plays a direct role in regulating tau expression at the post-transcriptional level.
- Stabilization of tau mRNA by SC35 represents a novel molecular mechanism contributing to tauopathies.
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