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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 4, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Modified dark room provocative test for primary angle closure.

Dejiao Li1, Ningli Wang, Bingsong Wang

  • 1Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, PR China.

Journal of Glaucoma
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

A modified dark room provocative test (DRPT) using anterior segment optical coherence tomography (AS-OCT) at 3 minutes is more precise for detecting primary angle closure than traditional gonioscopy after 1.5 hours. This enhanced DRPT improves diagnostic accuracy for anterior chamber angle abnormalities.

Related Experiment Videos

Last Updated: Jun 4, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Anterior Segment Imaging
  • Glaucoma Diagnostics

Background:

  • Primary angle closure is a significant cause of vision loss.
  • Accurate detection of anterior chamber angle abnormalities is crucial for timely intervention.
  • Traditional provocative tests have limitations in diagnostic precision.

Purpose of the Study:

  • To evaluate the diagnostic value of a modified dark room provocative test (DRPT).
  • To compare the efficacy of anterior segment optical coherence tomography (AS-OCT) with gonioscopy in detecting primary closure of the anterior chamber angle during a DRPT.

Main Methods:

  • A prospective clinical study involving 76 suspects of primary angle closure.
  • AS-OCT measured anterior chamber angle configuration at baseline and after 3 minutes of dark adaptation.
  • Gonioscopy and tonometry were performed at baseline and after 1.5 hours of dark adaptation; DRPT was positive if intraocular pressure increased by ≥8 mm Hg.

Main Results:

  • A modified DRPT using AS-OCT at 3 minutes identified more eyes with increased angle closure (91%) compared to gonioscopy at 1.5 hours (66%).
  • AS-OCT showed a significantly larger area under the receiver operator characteristics curve (0.86 vs. 0.73) in predicting a positive DRPT.
  • Moderate agreement was observed between AS-OCT and gonioscopy with the DRPT, with AS-OCT demonstrating higher sensitivity (90.6%) at 3 minutes.

Conclusions:

  • A modified DRPT incorporating AS-OCT assessment at 3 minutes of dark adaptation offers higher diagnostic precision for primary angle closure.
  • This method is superior to gonioscopic assessment after 1.5 hours of dark adaptation.
  • AS-OCT enhances the diagnostic capability of the DRPT for anterior chamber angle abnormalities.