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Related Concept Videos

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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Acute infarct selective MRI contrast agent.

Robert Kirschner1, Akos Varga-Szemes, Tamas Simor

  • 1Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, MCLM 556, Birmingham, AL 35294-0005, USA.

The International Journal of Cardiovascular Imaging
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

The contrast agent Gd(ABE-DTTA) effectively highlights myocardial infarcts in the early subacute phase but loses affinity as the infarct heals. This allows for early differentiation of infarct age using MRI imaging.

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MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Contrast Agents

Background:

  • Myocardial infarction (MI) diagnosis and age assessment are crucial for patient management.
  • Assessing infarct healing and scar formation requires advanced imaging techniques.
  • Contrast agents play a vital role in enhancing MRI visualization of cardiac tissue.

Purpose of the Study:

  • To evaluate the infarct affinity of the low molecular weight contrast agent Gd(ABE-DTTA) during the subacute phase of myocardial infarction (MI).
  • To determine if Gd(ABE-DTTA) can differentiate infarct age in the subacute healing phase.
  • To compare the performance of Gd(ABE-DTTA) with a conventional contrast agent, Gd(DTPA).

Main Methods:

  • A canine closed-chest, reperfused MI model was utilized.
  • Delayed-enhancement MRI (DE-MRI) with Gd(ABE-DTTA) was performed on days 4, 14, and 28 post-MI.
  • Control DE-MRI with Gd(DTPA) and T2-TSE imaging were also acquired.
  • Triphenyltetrazolium chloride (TTC) histomorphometry validated infarct presence postmortem.

Main Results:

  • Gd(ABE-DTTA) significantly highlighted infarcts on day 4 post-MI (signal intensity difference P < 0.05).
  • Infarct visualization by Gd(ABE-DTTA) diminished significantly by day 14 and was absent by day 28 (P < 0.05).
  • Gd(DTPA) effectively visualized the infarct on day 27, indicating sustained contrast enhancement.

Conclusions:

  • The infarct affinity of Gd(ABE-DTTA) diminishes during subacute scar healing.
  • Gd(ABE-DTTA) shows potential for early infarct age differentiation, immediately following the acute phase.
  • This characteristic allows for distinguishing recent MIs from older ones based on contrast agent uptake patterns.