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Double C-H activation: the palladium-catalyzed direct C-arylation of xanthines with arenes
Chandi C Malakar1, Dietmar Schmidt, Jürgen Conrad
1Institut für Chemie, Universität Hohenheim, Garbenstrasse 30, D-70599 Stuttgart, Germany.
Abstract:
The novel Pd-catalyzed C(sp(2))-H/C(sp(2))-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.
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