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Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
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NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation

Dmytro Puchkov1, Iryna Leshchyns'ka, Alexander G Nikonenko

  • 1Zentrum für Molekulare Neurobiologie, Universitätskrankenhaus Hamburg-Eppendorf, 20246 Hamburg, Germany.

Cerebral Cortex (New York, N.Y. : 1991)
|February 23, 2011
PubMed
Summary

Neural cell adhesion molecule (NCAM) deficiency or disruption of its spectrin complex increases postsynaptic density perforations. This structural change is linked to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) internalization and may impact brain pathologies.

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