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Updated: Jun 4, 2026
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Aortic Ring Assay
Published on: November 24, 2009
Rat Aortic Ring : 3D Model of Angiogenesis In Vitro
1Experimental Oncology Division, Institut de Rechèrches Servier, Suresnes, France.
Methods in Molecular Medicine
|February 23, 2011
Summary
Angiogenesis, the formation of new blood vessels, is crucial for tissue repair and tumor growth. Research focuses on understanding angiogenic factors and inhibitors using in vivo and in vitro assays.
Area of Science:
- Biomedical Sciences
- Cell Biology
- Pathology
Background:
- Angiogenesis is vital for normal tissue repair, tumor progression, and inflammatory diseases like diabetic retinopathy, rheumatoid arthritis, and psoriasis.
- Extensive research has focused on neovascularization regulation, particularly in tumors, over the past two decades.
- Efforts have concentrated on identifying angiogenic growth factors and inhibitory molecules, driven by the emphasis on tumor angiogenesis.
Purpose of the Study:
- To investigate the regulation of neovascularization.
- To characterize angiogenic growth factors and inhibitory molecules.
- To develop and utilize assays for measuring vascular growth and endothelial cell behavior.
Main Methods:
- Development of assays to measure in vivo vascular growth.
- Utilizing 2D culture systems to assess endothelial cell (EC) proliferation.
- Employing 2D culture systems to evaluate endothelial cell (EC) migration.
Main Results:
- Established assays for quantifying angiogenesis in vivo.
- Developed methods to measure endothelial cell proliferation in vitro.
- Developed methods to measure endothelial cell migration in vitro.
Conclusions:
- Assays have been developed to measure vascular growth in vivo.
- Assays allow for the modulation of endothelial cell proliferation in simple 2D culture systems.
- Assays enable the study of endothelial cell migration in simple 2D culture systems.
