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PAIRing for distal Igh locus V(D)J recombination

Chunguang Guo1, Frederick W Alt, Cosmas Giallourakis

  • 1Howard Hughes Medical Institute, The Children's Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Immunity
|February 26, 2011
PubMed
Summary

Researchers identified specific DNA sequences, called PAIR elements, in mouse immunoglobulin heavy chain genes. These elements are dependent on the Pax5 gene and may play a role in V(D)J recombination.

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