Recommendations for processing cardiovascular surgical pathology specimens: a consensus statement from the Standards

James R Stone1, Cristina Basso, Ulrik T Baandrup

  • 1Massachusetts General Hospital, Boston, MA 02114, USA. jrstone@partners.org

Insights

Proper processing of cardiovascular surgical pathology specimens is crucial for accurate diagnosis and patient care. This report provides consensus guidelines for handling diverse cardiac and vascular tissues to enhance diagnostic utility.

Area of Science:

  • Cardiovascular Pathology
  • Surgical Pathology
  • Molecular Disease Subclassification

Background:

  • Molecular subclassification of diseases necessitates optimized processing of cardiovascular surgical pathology specimens.
  • Diverse specimens, including biopsies, resected tissues, and explanted organs, require standardized handling.
  • Current practices may not fully leverage diagnostic potential for patient care.

Framework:

  • Consensus guidelines developed by the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology.
  • Standardized protocols for gross description, sectioning, processing, and staining.
  • Focus on maximizing diagnostic utility of various cardiovascular specimens.

Implementation:

  • Guidelines cover endomyocardial biopsies, cardiac myectomies, valves, aorta segments, tumors, grafts, devices, and explanted hearts.
  • Includes specific recommendations for arterial biopsies, such as temporal artery biopsies.
  • Aims to provide a unified approach for pathologists and clinicians.

Implications:

  • Enhanced patient care through improved diagnostic accuracy.
  • Maximizing the value of cardiovascular surgical pathology specimens.
  • Facilitating better understanding and management of cardiovascular diseases.