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[Optimization of extraction process of total alkaloids from radix of Aconitum flavum using response surface
Xiao-Juan Gao1, Zhi-Gang Ma, Lin Dong
1School of Pharmaceutical Science, Lanzhou University, Lanzhou 730030, China. gaoxiaojuan0705@126.com
Objective:
To study the technological parameters of the extraction process of total alkaloids from Radix of Aconitum flavum.
Methods:
Using response surface methodology (RSM) of three factors and three levels to optimize ethanol heat reflux applied for alkaloids extraction from Radix of Aconitum flavum.
Results:
A quadratic polynomial mathematical model with good correlation was constructed and employed to the optimization. The optimal extraction conditions were as follows: the extraction time was 1.72 h, the concentration of ethanol was 64.00%, the ratio of ethanol to raw material was 8.18 mL/g, under which the predictive value of the rate of extraction yield of alkaloids was 0.526% and the measured value was 0. 521%, respectively, and there was a good agreement with their predicted values.
Conclusion:
This reveals the good predictability of the mathematical model, the selected process also has a good reproducibility.
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Related Concept Videos
01:28Methods of Medium Optimization
01:16Response Surface Methodology
The process of RSM involves several key steps: