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[Prolactin adenomas in Dakar].

A G Diop1, M M Ndiaye, I P Ndiaye

  • 1Clinique Neurologique, C.H.U. de Fann, Dakar.

Dakar Medical
|January 1, 1990
PubMed
Summary

Prolactin adenomas are rare in Dakar, with late diagnosis often delaying treatment for women with amenorrhea-galactorrhea syndrome. Early detection via skull X-rays and prolactin level testing is crucial.

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Area of Science:

  • Neuroendocrinology
  • Neurosurgery
  • Radiology

Background:

  • Prolactin adenomas are rare pituitary tumors, often presenting with amenorrhea-galactorrhea syndrome.
  • Intracranial Expansive Processes (ICEP) in the sella region are dominated by craniopharyngiomas in Dakar.
  • A retrospective study analyzed 4 cases of prolactin adenomas among 63 ICEP cases.

Purpose of the Study:

  • To investigate the incidence and clinical presentation of prolactin adenomas in Dakar.
  • To highlight diagnostic challenges and treatment outcomes for prolactin adenomas.
  • To emphasize the importance of early detection and management.

Main Methods:

  • Retrospective analysis of 63 sella area ICEP cases from 1972-1987.
  • Clinical data review of 4 confirmed prolactin adenoma cases (women aged 20-38).
  • Paraclinical assessments including angiography, prolactin level measurement, and histological examination.

Main Results:

  • Patients presented late with symptoms of intracranial hypertension and visual field defects.
  • Angiography showed large sellar/sub-sellar masses; prolactin level testing was limited by cost and availability.
  • Histological confirmation of prolactinomas was obtained post-operatively; bromocriptine showed efficacy pre- and post-surgery.

Conclusions:

  • Prolactin adenomas appear rare in Dakar, with delayed diagnosis being a significant issue.
  • Improved diagnostic protocols including skull X-rays and prolactin level monitoring are recommended.
  • Bromocriptine is an effective medical treatment, often used adjunctively with surgery.

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