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[Antithrombin III in the Senegalese diabetic]
D Thiam1, W C Belem, M F Ndiaye
1Laboratoire d'Hématologie, Immunologie CHU Dakar.
Dakar Medical
|January 1, 1990
Summary
This study found that antithrombin III activity decreases with age in Senegalese adults, particularly those with obesity and diabetes complications. However, insulin dependence did not affect antithrombin III effectiveness in diabetic patients.
Area of Science:
- Biochemistry
- Hematology
- Endocrinology
Background:
- Antithrombin III (AT III) is a crucial anticoagulant protein.
- Age, obesity, and diabetes complications can affect coagulation factors.
- Understanding AT III's physiological activity is vital for managing thrombotic risks.
Purpose of the Study:
- To investigate the physiological activity of Antithrombin III (AT III) in Senegalese adults.
- To determine the influence of age, obesity, and diabetes on AT III activity.
- To assess the impact of insulin dependence on AT III effectiveness in diabetic patients.
Main Methods:
- Chronometric method applied to 141 diabetic and 151 reference subjects.
- Participants were of Black race and Senegalese nationality, aged 19-60 years.
- Data analysis correlated AT III activity with age, obesity, and diabetic complications.
Main Results:
- A significant reduction in AT III physiological activity was observed in age groups 36-45 and 56-60.
- Reduced AT III activity correlated with obesity and other diabetic complications.
- Insulin dependence did not appear to reduce AT III effectiveness in the studied diabetic patients.
Conclusions:
- Age and obesity are significant factors influencing AT III activity in this population.
- Diabetes complications, but not insulin dependence, are associated with reduced AT III effectiveness.
- Further research may elucidate specific mechanisms linking obesity and AT III function.