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Updated: Jun 4, 2026

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
Published on: April 1, 2015
Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for
Neil J Rawlinson1, Bonita Fung, Thomas G Gross
1Department of Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Abstract:
Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy.
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