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Related Experiment Videos

Urinary zinc excretion in infancy.

E Sievers1, H D Oldigs, K Dörner

  • 1Department of Pediatrics, University of Kiel, Fed. Rep. of Germany.

Journal of Trace Elements and Electrolytes in Health and Disease
|March 1, 1990
PubMed
Summary

Urinary zinc excretion in infants declines with age, with lower levels observed in breast-fed infants compared to formula-fed infants. Proper urine collection methods are crucial to avoid contamination and ensure accurate zinc excretion measurements.

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Area of Science:

  • Pediatric Nutrition
  • Clinical Chemistry
  • Trace Element Metabolism

Background:

  • Conflicting data exists regarding urinary zinc excretion in infants.
  • Factors like contamination, collection methods, and nutrition may influence results.

Purpose of the Study:

  • To investigate the influence of contamination, collection methods, nutrition, and longitudinal changes on infant urinary zinc excretion.
  • To establish reference values for urinary zinc excretion in healthy infants.

Main Methods:

  • Investigated contamination sources, including zinc-containing creams.
  • Evaluated urine collection techniques, recommending midstream samples and avoidance of skin contamination.
  • Compared urinary zinc excretion in breast-fed versus formula-fed infants over 16 weeks.
  • Monitored preterm infants on specific medications.

Main Results:

  • Special attention to avoiding contamination from zinc-containing creams is necessary.
  • Midstream urine samples and avoiding skin contamination reduce erroneous high values.
  • Median daily urinary zinc excretion significantly declined in healthy breast-fed infants from 2 to 16 weeks.
  • Formula-fed infants showed comparable, but initially higher, zinc excretion levels.

Conclusions:

  • Established reference values for urinary zinc excretion in healthy term infants.
  • Highlighted the importance of meticulous collection methods to prevent contamination.
  • Demonstrated significant longitudinal changes in urinary zinc excretion influenced by feeding type.

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