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Related Concept Videos

Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

The coded functions of noncoding RNAs for gene regulation.

Sojin An1, Ji-Joon Song

  • 1Structural Biology Laboratory of Epigenetics, Department of Biological Sciences, Graduate School of Nanoscience and Technology (World Class University), KI Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.

Molecules and Cells
|March 2, 2011
PubMed
Summary

Noncoding RNAs (ncRNAs) are crucial for fine-tuning gene expression in eukaryotes. This review discusses new findings on how ncRNAs regulate gene expression through diverse mechanisms like mRNA degradation and epigenetic modification.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gene Regulation

Background:

  • Eukaryotic gene expression requires precise coordination of complex genetic information.
  • Noncoding RNAs (ncRNAs) have emerged as critical regulators in this process.
  • ncRNAs are involved in diverse cellular functions, including mRNA degradation, epigenetic regulation, and alternative splicing.

Purpose of the Study:

  • To review recent findings on the role of ncRNAs in eukaryotic gene regulation.
  • To highlight the complexity and subtlety of gene regulation mechanisms involving ncRNAs.

Main Methods:

  • Literature review of recent studies on ncRNA function in gene regulation.
  • Synthesis of current knowledge on ncRNA-mediated gene expression control.

Main Results:

  • ncRNAs play central roles in fine-tuning gene expression.
  • ncRNAs participate in diverse regulatory functions such as mRNA degradation, epigenetic regulation, and alternative splicing.
  • The involvement of ncRNAs reveals a more complex gene regulation landscape than previously understood.

Conclusions:

  • Noncoding RNAs are essential for intricate gene expression control in eukaryotes.
  • Understanding ncRNA mechanisms provides deeper insights into gene regulation.
  • Further research into ncRNAs will continue to unveil the subtleties of genetic information coordination.