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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Propylthiouracil-induced nonspecific interstitial pneumonia.

Ji Yeon Lee1, Jin-Haeng Chung2, Yeon Joo Lee1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul.

Chest
|March 3, 2011
PubMed
Summary

Propylthiouracil (PTU) can cause rare lung issues. This case report details the first instance of PTU-induced nonspecific interstitial pneumonia (NSIP), confirmed by biopsy, resolving after drug withdrawal.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Internal Medicine

Background:

  • Propylthiouracil (PTU) is a common medication for hyperthyroidism.
  • Adverse effects of PTU include fever, rash, and agranulocytosis.
  • PTU-induced interstitial pneumonia is a rare but serious adverse effect.

Observation:

  • A patient developed dyspnea, cough, and fever after one year of PTU treatment.
  • Chest CT revealed multifocal patchy consolidation in both lungs.
  • Surgical lung biopsy confirmed nonspecific interstitial pneumonia (NSIP).

Findings:

  • This is the first reported case of pathologically proven Propylthiouracil-induced nonspecific interstitial pneumonia (NSIP).
  • Patient symptoms and radiographic abnormalities improved after discontinuing PTU.
  • Nonspecific interstitial pneumonia (NSIP) should be considered in patients on PTU presenting with respiratory symptoms.

Implications:

  • Highlights a rare but significant pulmonary adverse effect of Propylthiouracil (PTU).
  • Emphasizes the importance of considering drug-induced lung disease in differential diagnosis.
  • Suggests prompt PTU withdrawal may lead to resolution of PTU-induced NSIP.