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Updated: Jun 4, 2026
07:10
Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Update on human immunodeficiency virus (HIV)-2 infection
Omobolaji T Campbell-Yesufu1, Rajesh T Gandhi
1Massachusetts General Hospital, Boston, Massachusetts, USA. gandhi@partners.org
Summary
Human immunodeficiency virus type 2 (HIV-2) infection is spreading globally. This review covers recent advances in diagnosing and treating HIV-2, addressing ongoing challenges.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Human immunodeficiency virus type 2 (HIV-2) primarily affects West Africa but is increasingly detected globally.
- Clinicians require awareness of HIV-2 diagnosis and testing protocols due to global integration.
- Recent clinical trials offer new insights into treatment options for HIV-2 infection.
Purpose of the Study:
- To review recent clinical advances in understanding HIV-2 infection.
- To highlight current diagnostic and therapeutic challenges associated with HIV-2.
- To inform clinicians about the evolving landscape of HIV-2 management.
Main Methods:
- Literature review of recent clinical trials and studies on HIV-2.
- Synthesis of information on diagnostic criteria and testing strategies.
- Analysis of current and emerging treatment options for HIV-2.
Main Results:
- Increasing recognition of HIV-2 cases outside West Africa.
- Emerging data on treatment efficacy and regimens for HIV-2.
- Identification of persistent gaps in diagnosis and therapy.
Conclusions:
- Global vigilance for HIV-2 infection is crucial.
- Advances in treatment are providing more options, though challenges remain.
- Further research is needed to address diagnostic and therapeutic hurdles in HIV-2 management.
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