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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 4, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Synchronous squamous cell carcinoma in multiple digits.

Sabra Abner, Jeremiah Redstone, Saeed Chowdhry

    Eplasty
    |March 4, 2011
    PubMed
    Summary

    Squamous cell carcinoma of the nail bed is rare but can occur synchronously on multiple digits. Early diagnosis via biopsy is crucial for preserving hand function and optimal treatment.

    Area of Science:

    • Oncology
    • Dermatology
    • Hand Surgery

    Background:

    • Cancers of the perionychium (nail unit) are uncommon, often linked to chronic inflammation from trauma, infection, UV radiation, or carcinogens.
    • Squamous cell carcinoma (SCC) is the most frequent nail bed tumor.
    • Synchronous SCCs of the perionychium are exceptionally rare.

    Purpose of the Study:

    • To report a rare case of synchronous squamous cell carcinomas affecting both hands and multiple digits.
    • To highlight the importance of early diagnosis and treatment for preserving hand function.

    Main Methods:

    • Case presentation of a 46-year-old woman with synchronous SCCs.
    • Discussion of treatment modalities including chemotherapeutics, Mohs surgery, and amputation.

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    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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    Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
    06:15

    Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

    Published on: August 9, 2024

    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
    07:53

    Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

    Published on: March 17, 2020

    Main Results:

    • The patient presented with synchronous SCCs involving both hands and multiple digits.
    • Treatment involved a combination of therapies, potentially including amputation.

    Conclusions:

    • Early diagnosis of nail bed SCC significantly improves the chances of preserving hand function.
    • Onychomycosis can be an initial symptom or a predisposing factor for SCC, especially in individuals with occupational exposures.
    • Clinicians should maintain a high index of suspicion for SCC in relevant cases to facilitate timely diagnosis via biopsy and appropriate management.