Quantitative measurement of cell-cell adhesion under flow conditions

Cell-cell and cell-matrix contacts play an important role in immunological processes and tissue organization. It has been shown that in many cases, cell adhesion is mediated by specialized adhesion receptors that are typically anchored in the cell membrane with mol wt ranging from 50 to 200 kDa. Binding of adhesion receptors anchored in the apposing cell membranes with their counterligands appears to be critical for many forms of cell-cell communication (1).