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Published on: April 28, 2020
Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning
Yuan-qiang Lu1, Jiu-kun Jiang, Wei-dong Huang
1Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. luyuanqiang@yahoo.cn
Objective:
To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.
Methods:
A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.
Results:
Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.
Conclusions:
Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.
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