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Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Related Experiment Video

Updated: Jun 3, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Longitudinal hemodiafilter performance in modeled continuous renal replacement therapy.

Deborah A Pasko1, Mariann D Churchwell, Noha N Salama

  • 1Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Mich., USA.

Blood Purification
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

Continuous renal replacement therapy (CRRT) circuit duration impacts hemodiafilter performance. Creatinine and gentamicin clearance declined over 48 hours, especially with polysulfone filters, affecting dialysis dose and drug clearance.

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Last Updated: Jun 3, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Many institutions extend continuous renal replacement therapy (CRRT) circuit duration beyond manufacturer recommendations.
  • Extended use may alter hemodiafilter performance and solute clearance properties.
  • Hemodiafilter performance over time has not been previously assessed.

Purpose of the Study:

  • To investigate solute clearance over time in modeled CRRT circuits.
  • To assess the impact of hemodiafilter age on clearance in vitro.

Main Methods:

  • In vitro continuous hemofiltration (CH) and continuous hemodialysis (CD) were performed for 48 hours.
  • Four hemodiafilter types (AN69, cellulose triacetate, F70 polysulfone, Optiflux F160NR polysulfone) were tested with citrated bovine blood.
  • Clearances of urea, creatinine, gentamicin, vancomycin, and albumin were measured under varying ultrafiltration and dialysate flow rates.

Main Results:

  • Solute clearances in CH were higher at 3 l/h ultrafiltration rate.
  • Only creatinine and gentamicin clearances were significantly affected by time.
  • Creatinine clearance declined significantly by 48 hours for all hemodiafilters, particularly polysulfone types.

Conclusions:

  • The duration of CRRT circuits influences solute transmembrane clearance.
  • Hemodiafilter age is a critical factor to consider when evaluating dialysis dose or drug clearance in CRRT patients.