Related Experiment Video

Updated: Jun 3, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
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Published on: October 4, 2021

[Development of secondary resistance to dopamine agonists in a patient with giant prolactinoma]

L I Astaf'eva, B A Kadashev, Iu Iu Trunin

    Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
    |March 8, 2011
    PubMed

    Insights

    Dopamine agonist resistance in prolactinoma is rare. Radiation therapy offers an effective alternative for managing secondary resistance in macroadenomas when surgery is not feasible.

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Oncology

    Background:

    • Dopamine agonists are the primary treatment for prolactinoma.
    • 10-20% of patients exhibit resistance to dopamine agonists, with a subset developing secondary resistance after initial response.
    • Surgery may be challenging for large, invasive adenomas.

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