Related Experiment Video
Updated: Jun 3, 2026
13:47
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
Summary
A new database compiles mutations and SNPs in key genes (MYOC, OPTN, CYP1B1, WDR36) linked to primary open-angle glaucoma (POAG). This resource aids in understanding glaucoma
Area of Science:
- Ophthalmology
- Genetics
- Bioinformatics
Background:
- Glaucoma is a leading cause of optic nerve blindness globally.
- Primary open-angle glaucoma (POAG) is the most common form, affecting millions.
- MYOC, OPTN, CYP1B1, and WDR36 are significant candidate genes for glaucoma.
Purpose of the Study:
- To compile and integrate mutation and SNP data for key glaucoma-associated genes.
- To develop a centralized database for accessing genetic information related to glaucoma.
- To facilitate statistical and clinical analysis of specific mutations and SNPs.
Main Methods:
- Data compilation of mutations and Single Nucleotide Polymorphisms (SNPs) in MYOC, OPTN, CYP1B1, and WDR36.
- Development of a SQL-based database to store genetic and associated study data.
- Making the database accessible online for public use.
Main Results:
- A comprehensive database of mutations and SNPs in MYOC, OPTN, CYP1B1, and WDR36 has been created.
- The database includes statistical and clinical information relevant to specific genetic variations.
- The resource is available online at http:bicmku.in:8081/glaucoma.
Conclusions:
- The developed database serves as a valuable resource for researchers studying glaucoma genetics.
- It enables easier access to critical genetic data for understanding POAG.
- This tool can aid in the statistical and clinical investigation of glaucoma-related mutations and SNPs.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...