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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

(4+3) cycloaddition reactions of nitrogen-stabilized oxyallyl cations

Andrew G Lohse1, Richard P Hsung

  • 1Division of Pharmaceutical Sciences, Department of Chemistry, University of Wisconsin, Madison, Madison, WI 53705, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 9, 2011
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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