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Updated: Jun 3, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice
Tohru Sakai1, Sakina Furoku, Mariko Nakamoto
1Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tohrus@nutr.med.tokushima-u.ac.jp
Abstract:
The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.
