Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methods for predicting migration to packaged pharmaceuticals.

H Kim-Kang1, S G Gilbert, A W Malick

  • 1Department of Food Science, Rutgers University, Cook College, New Brunswick, NJ 08903.

Journal of Pharmaceutical Sciences
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infrasound detection of approaching lahars.

Scientific reports·2023
Same author

Diuretic, Sedative and Diaphoretic Pill.

The Southern medical record·2022
Same author

Modulatory effects of Zn<sup>2+</sup> ions on the toxicity of citrate- and PVP-capped gold nanoparticles towards freshwater algae, Scenedesmus obliquus.

Environmental science and pollution research international·2016
Same author

Surface capping and size-dependent toxicity of gold nanoparticles on different trophic levels.

Environmental science and pollution research international·2015
Same author

Co-occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2015
Same author

Sexual selection on female ornaments in the sex-role-reversed Gulf pipefish (Syngnathus scovelli).

Journal of evolutionary biology·2014
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

Evaluating pharmaceutical product compatibility with packaging is crucial. This study shows efficient analytical methods can assess potential migrants from materials like PET containers and adhesives.

Area of Science:

  • Pharmaceutical Science
  • Analytical Chemistry
  • Materials Science

Background:

  • Pharmaceutical product compatibility with packaging is critical for drug development and stability.
  • Regulatory agencies like the FDA provide methodologies for evaluating packaging materials.
  • Assessing potential migrants from packaging is essential to ensure product safety and efficacy.

Purpose of the Study:

  • To explore efficient modifications of existing FDA methodologies for packaging material assessment.
  • To demonstrate the application of current analytical techniques for evaluating packaging migrants.
  • To address common questions regarding packaging materials in pharmaceutical stability studies.

Main Methods:

  • Review and adaptation of relevant FDA methodologies.

Related Experiment Videos

  • Application of current analytical techniques to identify and quantify potential migrants.
  • Case studies involving heat-seal adhesives, amber PET containers, and rubber gaskets.

    • Main Results:

    • Demonstrated that available analytical techniques can efficiently assess potential migrants from various packaging materials.
    • Showcased successful application of modified FDA methodology in real-world scenarios.
    • Provided evidence that common packaging-related stability questions can be effectively answered.

    Conclusions:

    • Modified FDA methodologies using current analytical techniques offer a more efficient approach to packaging material assessment.
    • The presented studies confirm the feasibility and effectiveness of this approach for pharmaceutical development.
    • This strategy facilitates robust evaluation of packaging integrity and product safety.