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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Published on: December 18, 2016

Quantitative mapping of T2 using partial spoiling.

Oliver Bieri1, Klaus Scheffler, Goetz H Welsch

  • 1Division of Radiological Physics, Department of Medical Radiology, University of Basel Hospital, Basel, Switzerland. oliver.bieri@unibas.ch

Magnetic Resonance in Medicine
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

A new, fast MRI technique accurately maps T2 relaxation times in human brain and cartilage. This method uses partially spoiled steady-state free precession for rapid, quantitative tissue analysis.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Quantitative Imaging

Background:

  • Quantitative MRI offers advanced tissue characterization beyond conventional imaging.
  • Steady-state free precession (SSFP) techniques are gaining interest for rapid relaxation time quantification.

Purpose of the Study:

  • Introduce and validate a novel, fast T2 mapping technique using partially spoiled SSFP.
  • Assess the accuracy and feasibility of this new method for in vivo quantitative MRI.

Main Methods:

  • Developed a new T2 mapping technique based on partial RF spoiling of nonbalanced SSFP.
  • Evaluated the technique through simulations and in vivo human studies at 1.5 T, 3.0 T, and 7.0 T.
  • Compared results with a reference multicontrast spin-echo technique.

Main Results:

  • Obtained T2 values for human gray and white matter (60-100 msec).
  • Observed spatial T2 variations in human articular cartilage (33-54 msec).
  • Demonstrated excellent agreement between the new SSFP method and the reference technique.

Conclusions:

  • The proposed partially spoiled SSFP technique provides fast and accurate T2 mapping.
  • The method is feasible for high-resolution quantitative imaging in various tissues, including cartilage at ultra-high fields.