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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Maxwell's Thermodynamic Relations01:23

Maxwell's Thermodynamic Relations

Maxwell's thermodynamic relations are very useful in solving problems in thermodynamics. Each of Maxwell's relations relates a partial differential between quantities that can be hard to measure experimentally to a partial differential between quantities that can be easily measured. These relations are a set of equations derivable from the symmetry of the second derivatives and the thermodynamic potentials.
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Thermal Sigmatropic Reactions: Overview01:16

Thermal Sigmatropic Reactions: Overview

Sigmatropic rearrangements are a class of pericyclic reactions in which a σ bond migrates from one part of a π system to another. These are intramolecular rearrangements where the total number of σ and π bonds remain unchanged.
Sigmatropic shifts are classified based on an order term [i, j ], where i and j indicate the number of atoms across which each end of the σ bond migrates. Below are examples of a [3,3] sigmatropic shift in 1,5-hexadiene, referred to as...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

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Related Experiment Video

Updated: Jun 3, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

Multipathway sequences for MR thermometry.

Bruno Madore1, Lawrence P Panych, Chang-Sheng Mei

  • 1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. bruno@bwh.harvard.edu

Magnetic Resonance in Medicine
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

New MR thermometry techniques improve temperature accuracy and lesion tracking during thermal ablation. This advancement enhances safety and effectiveness for treatments in mobile organs like the liver and kidneys.

Related Experiment Videos

Last Updated: Jun 3, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

Area of Science:

  • Medical Imaging
  • Interventional Radiology
  • Biophysics

Background:

  • Magnetic Resonance (MR)-based thermometry is crucial for guiding thermal ablation therapies.
  • Accurate temperature monitoring ensures lethal doses are delivered to targets while sparing healthy tissues.
  • Tracking mobile lesions is challenging but essential for effective treatment in organs like the liver and kidneys.

Purpose of the Study:

  • To introduce novel pulse sequence modifications for MR thermometry.
  • To enhance temperature-to-noise ratio (TNR) properties.
  • To improve target-tracking capabilities for mobile lesions.

Main Methods:

  • Modified MR pulse sequences sampling at least one additional magnetization pathway.
  • Image reconstruction techniques adapted for the new sampling scheme.
  • Implementation on gradient-echo and interleaved echo-planar imaging sequences.

Main Results:

  • Achieved temperature-to-noise ratio improvements of up to 35% without increasing scan time.
  • Demonstrated significantly different contrast for blood vessels across sampled pathways, aiding landmark detection.
  • Enabled enhanced lesion tracking for improved treatment accuracy.

Conclusions:

  • The proposed pulse-sequence design offers substantial improvements in MR thermometry.
  • Enhanced TNR and lesion-tracking facilitate MR-guided thermal ablations in mobile organs.
  • This advancement may broaden the applicability of MR-monitored thermal ablation therapies.