Related Experiment Video
Updated: Jun 3, 2026
05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Management of feto-maternal red cell allo-immunizations]
P Bricca1, E Guinchard, C Guitton Bliem
1EFS Rhône-Alpes, site du groupement hospitalier Est, 28, avenue du Doyen Lépine, 69677 Bron cedex, France. pascaline.bricca@efs.sante.fr
Summary
Feto-maternal red cell alloimmunization occurs when a pregnant woman develops antibodies against fetal red blood cells, potentially causing hemolytic disease. Early detection and monitoring using new non-invasive techniques are crucial for managing this condition.
Area of Science:
- Immunology
- Obstetrics
- Neonatology
Background:
- Feto-maternal red cell alloimmunization involves maternal antibodies targeting fetal red blood cell antigens.
- This immune response can stem from prior transfusions, transplants, or pregnancies.
- Antibody transfer across the placenta causes fetal hemolysis, leading to varied clinical outcomes.
Purpose of the Study:
- To outline management strategies for feto-maternal alloimmunization.
- To highlight the importance of detecting and monitoring maternal alloimmunization.
- To assess the impact of alloimmunization on the fetus and newborn.
Main Methods:
- Utilizing non-invasive surveillance techniques like fetal RHD genotyping from maternal plasma.
- Employing middle cerebral artery blood flow velocimetry to evaluate fetal anemia.
- Emphasizing careful postnatal surveillance for prolonged neonatal anemia and jaundice.
Main Results:
- New non-invasive techniques aid in fetal surveillance.
- Postnatal monitoring is essential due to risks of prolonged anemia and severe neonatal jaundice.
- Improved biological techniques can enhance the targeting of women for anti-RH1 alloimmunization prevention.
Conclusions:
- Effective management of feto-maternal alloimmunization requires early detection and monitoring.
- Non-invasive methods improve fetal assessment and surveillance.
- Advancements in biological techniques offer better prevention strategies for alloimmunization.
Related Concept Videos
01:19Rh Blood Group
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:12The ABO Blood Group
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...