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Updated: Jun 3, 2026

System for Focal, Closed-System Central Nervous System Injury
Published on: November 29, 2024
[Clinicomorphological classifications of perinatal central nerve system lesions]
Abstract:
The paper describes a critical approach to the existing clinical classifications of central nerve system (CNS) lesion, which do not consider a morphological substrate. It proposes the clinical and morphological directionality of the major classifications of brain lesions: intraventricular, leptomeningeal, and cerebellar hemorrhages and periventricular leukomalacia. The differential diagnosis of periventricular leukomalacia with teleencephalic gliosis, edematous hemorrhagic leukoencephalopathy and other brain lesions. This is a discordance between the clinical, neurosonographic, and morphological classifications of perinatal CNS lesions. The author proposes to elaborate the clinical, morphological, and functional criteria for the differential diagnosis of brain lesions in children, by taking their pathomorphology as a basis.
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