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Updated: Jun 3, 2026

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Hypergammaglobulinemia in an SIV-infected rhesus macaque with a B-cell neoplasm with plasma cell differentiation
Joshua A Kramer1, Brigitte E Sanders-Beer, Yvette Edghill Spano
1Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA.
Abstract:
An SIV-infected rhesus macaque presented with anemia, hypercalcemia, and hyperglobulinemia. Neoplastic round cells with plasma cell morphology infiltrated multiple organs and stained immunohistochemically positive for CD45, MUM1/IRF4, CD138, VS38C, and Kappa light chain and variably positive for CD20 and CD79a, consistent with a B-cell neoplasm with plasma cell differentiation.
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