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Etanercept compared to intraarticular corticosteroid injection in rheumatoid arthritis: double-blind, randomized
Christian H Roux1, Veronique Breuil, Laure Valerio
1Rheumatology Department, Hospital l'Archet 1, 242 Route de Saint Antoine de Ginestiere, 06200 Nice, France. roux101fr@yahoo.fr
Objective:
To compare etanercept (anti-tumor necrosis factor-α) with intraarticular (IA) corticosteroid injections to treat rheumatoid arthritis (RA).
Methods:
Patients with RA who had persistent monoarthritis received etanercept or IA corticosteroid injections. Efficacy was compared at Weeks 4 and 24.
Results:
Thirty-four patients were included (8 dropped out). Mean age was 58.8 years. No difference between groups was found at Weeks 4 or 24, but both groups showed significant improvement at Weeks 4 and 24 compared to baseline.
Conclusion:
Etanercept and IA steroid injections resulted in significant improvement at Week 4 that persisted to Week 24. There was no significant difference in outcome between the groups.
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