Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E
Fumihiko Yasuno1, Satoshi Tanimukai, Megumi Sasaki
1Department of Neuropsychiatry, National Cerebral and Cardiovascular Center, Osaka, Japan. yasunof@hsp.ncvc.go.jp
Summary
Plasma apolipoprotein E (apoE) positively influences cognitive function in older adults, regardless of APOE4 genotype. High-density lipoprotein (HDL) benefits cognition only in those without the APOE4 variant.
Area of Science:
- Neuroscience
- Gerontology
- Biochemistry
Background:
- The link between cognitive function and plasma lipids is complex, with prior research yielding inconsistent findings.
- Genetic factors, particularly apolipoprotein E (APOE) genotype, may confound the relationship between lipids and cognition.
Purpose of the Study:
- To investigate the association between plasma lipid levels and cognitive function in older adults.
- To examine these associations while controlling for apolipoprotein E (APOE) genotype status.
Main Methods:
- 1,395 non-demented subjects aged 65+ were recruited and categorized based on APOE4 genotype (E4+ and E4-).
- Plasma levels of HDL, LDL, TG, TC, and apoE were measured.
- Cognitive function was assessed, and its association with lipid profiles was analyzed within each APOE genotype group.
Main Results:
- A positive correlation between cognitive scores and plasma apoE levels was observed in both E4- and E4+ groups.
- Cognitive scores showed a positive association with HDL levels exclusively in the E4- group.
- No significant associations were found between cognitive scores and LDL, TG, or TC levels in either group.
Conclusions:
- Plasma apoE positively impacts cognitive function across all participants, irrespective of APOE4 genotype.
- Plasma HDL demonstrates a beneficial effect on cognition solely in individuals without the APOE4 genotype.
- Understanding the interplay between APOE genotype, apoE, and HDL metabolism may inform novel strategies for mitigating age-related cognitive decline.
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