Related Experiment Video
Updated: Jun 3, 2026
08:34
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
[Research advances on coregulators in adipocyte differentiation].
1College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|March 23, 2011
Summary
Coregulators, which modulate gene transcription without binding DNA, are crucial for adipocyte differentiation. This review covers recent advances in understanding coactivators and corepressors in this process.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Context:
- Adipocyte differentiation is a complex process regulated by various molecular factors.
- Coregulators are essential trans-acting factors that modulate gene transcription.
- Understanding coregulator function is key to deciphering adipogenesis.
Purpose:
- To summarize recent advances in the study of coregulators in adipocyte differentiation.
- To highlight the roles of coactivators and corepressors in this process.
- To provide an overview of the current understanding of coregulator involvement in adipogenesis.
Summary:
- Coregulators are proteins that do not bind DNA but interact with transcription factors to control gene expression.
- Recent research indicates significant roles for coregulators, including coactivators and corepressors, in adipocyte differentiation.
- This paper reviews the latest findings on these factors during the development of fat cells.
Impact:
- Provides a consolidated resource for researchers studying adipocyte differentiation.
- Enhances understanding of the molecular mechanisms governing fat cell development.
- May inform future therapeutic strategies targeting metabolic disorders related to adipogenesis.
Related Concept Videos
00:57Cellular Differentiation
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:19Regulation of Metabolism
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...