Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Mawson, A.R.; Croft, A.M. Multiple Vaccinations and the Enigma of Vaccine Injury. <i>Vaccines</i> 2020, <i>8</i>, 676.

Vaccines·2026

Same author

Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis.

Viral immunology·2021

Same author

Multiple Vaccinations and the Enigma of Vaccine Injury.

Vaccines·2020

Same author

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.

International journal of environmental research and public health·2019

Same author

Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem.

International journal of environmental research and public health·2019

Same author

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives.

Malaria journal·2016

Same journal

Rheumatoid arthritis: previously untreated early disease.

BMJ clinical evidence·2016

Same journal

Diabetic retinopathy: intravitreal vascular endothelial growth factor inhibitors for diabetic macular oedema.

BMJ clinical evidence·2016

Same journal

Subarachnoid haemorrhage (spontaneous aneurysmal).

BMJ clinical evidence·2016

Same journal

Malaria: fluid therapy in severe disease.

BMJ clinical evidence·2016

Same journal

Age-related macular degeneration: anti-vascular endothelial growth factor treatment.

BMJ clinical evidence·2016

Same journal

MRSA: treating people with infection.

BMJ clinical evidence·2016

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Malaria: prevention in travellers.

Ashley M Croft¹

¹Ministry of Defence, London, UK.

BMJ Clinical Evidence

|March 23, 2011

Summary

This summary is machine-generated.

This systematic review evaluates malaria prevention strategies for travelers, including drug prophylaxis, vaccines, and non-drug interventions like insect repellents and protective clothing. It assesses the effectiveness and safety of various antimalaria measures for different traveler groups.

More Related Videos

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Area of Science:

Travel Medicine
Infectious Disease Epidemiology
Public Health

Background:

Malaria transmission is linked to specific environmental conditions (humidity >60%, temperature 25-30°C).
Travel duration and activity influence malaria risk.
Incubation periods vary from 10 days to 18 months, depending on the parasite strain.

Purpose of the Study:

To systematically review the effectiveness and safety of non-drug preventive interventions for non-pregnant adult travelers.
To evaluate drug prophylaxis options for non-pregnant adult travelers.
To assess antimalaria vaccines and interventions for child, pregnant travelers, and airline pilots.

Main Methods:

Systematic review of 79 studies including systematic reviews, RCTs, and observational studies.
Searched major databases (Medline, Embase, Cochrane Library) up to November 2009.
Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

The review identified numerous interventions for malaria prevention.
Evidence quality was evaluated using the GRADE system.
A comprehensive list of interventions was assessed for effectiveness and safety.

Conclusions:

The review provides information on the effectiveness and safety of a wide range of antimalaria interventions.
Interventions covered include insecticides, repellents (DEET), clothing, nets, antimalarial drugs (mefloquine, doxycycline, etc.), and vaccines.
This systematic review synthesizes evidence for informed decision-making in malaria prevention for travelers.