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Updated: Jun 3, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
Sleep disorders in children
Oliveiero Bruni1, Luana Novelli
1Sapienza University, Rome, Italy.
Insights
This systematic review examines treatments for childhood sleep disorders, including dyssomnias and parasomnias. Evidence was evaluated for interventions like behavioral therapy, melatonin, and sleep hygiene.
Area of Science:
- Pediatrics
- Sleep Medicine
- Clinical Evidence Synthesis
Background:
- Sleep disorders affect 20-30% of young children, encompassing dyssomnias (difficulty sleeping) and parasomnias (sleepwalking, night terrors).
- Children with disabilities face a higher risk of developing sleep disorders.
Purpose of the Study:
- To systematically review the effects of treatments for dyssomnias in children.
- To systematically review the effects of treatments for parasomnias in children.
Main Methods:
- Systematic review of studies including systematic reviews, randomized controlled trials (RCTs), and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to September 2009.
- Included safety alerts from regulatory agencies (FDA, MHRA).
Main Results:
- 28 relevant studies were identified and included in the review.
- A GRADE evaluation assessed the quality of evidence for various interventions.
- Information on the effectiveness and safety of numerous treatments was compiled.
Conclusions:
- The review synthesizes evidence on interventions for pediatric sleep disorders.
- Interventions covered include behavioral therapy, medications (antihistamines, benzodiazepines, melatonin), light therapy, and sleep strategies.
- Safety and effectiveness data are presented for a range of treatments for both dyssomnias and parasomnias.
Introduction:
Sleep disorders may affect between 20% and 30% of young children, and include problems getting to sleep (dyssomnias), or undesirable phenomena during sleep (parasomnias), such as sleep terrors and sleepwalking. Children with physical or learning disabilities are at increased risk of sleep disorders.
Methods And Outcomes:
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for dyssomnias in children? What are the effects of treatments for parasomnias in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results:
We found 28 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions:
In this systematic review we present information relating to the effectiveness and safety of the following interventions: antihistamines; behavioural therapy plus antihistamines, plus benzodiazepines, or plus chloral and derivatives; benzodiazepines alone; exercise; extinction and graduated extinction; 5-hydroxytryptophan; light therapy; melatonin; safety/protective interventions for parasomnias; scheduled waking (for parasomnias); sleep hygiene; and sleep restriction.
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