[Clinical observation of posterior polymorphous corneal dystrophy]

Area of Science:

• Ophthalmology
• Corneal Diseases
• Microscopy

Context:

• Posterior polymorphous corneal dystrophy (PPCD) is a rare genetic eye condition.
• Understanding its clinical features and microscopic findings is essential for diagnosis and management.

Purpose:

• To investigate the clinical manifestations and in vivo confocal microscopic characteristics of posterior polymorphous corneal dystrophy (PPCD).

Summary:

• This study analyzed 10 patients with PPCD, detailing their ages, lesion types (vesicular, band-like, diffused opacities), and associated complications like iridocorneal adhesions.
• Specular microscopy revealed significantly larger endothelial cells and reduced density in affected eyes compared to normal eyes.
• In vivo confocal microscopy identified endothelial polymorphism, bright nuclei, and various lesions such as finger-like projections and dike-like appearances.

Impact:

• The findings emphasize the importance of slit-lamp examination for initial PPCD diagnosis, with specular microscopy and in vivo confocal microscopy providing confirmation.
• Abnormal corneal topography and potential association with elevated intraocular pressure were noted, highlighting the need for comprehensive ophthalmic evaluation.