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Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy

Published on: April 27, 2021

Gene circuit designs for noisy excitable dynamics.

Pau Rué¹, Jordi Garcia-Ojalvo

¹Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Edifici GAIA, Barcelona, Spain.

Mathematical Biosciences

|March 23, 2011

Summary

Molecular noise can drive cellular processes into activity pulses, resembling noise-driven excitable dynamics. Gene circuit designs can exhibit these protein expression pulses, with dynamics varying based on system parameters and bifurcation structures.

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Area of Science:

Systems Biology
Biophysics
Molecular Biology

Background:

Cellular processes often manifest as activity pulses.
These pulses can be modeled using noise-driven excitable dynamics.
Molecular noise plays a crucial role in biological systems.

Purpose of the Study:

To provide an overview of gene circuit architectures that generate excitable protein expression pulses under molecular noise.
To explore the relationship between bifurcation structures, phase-space topology, and excitable dynamics.
To demonstrate how different excitable dynamics can arise from the same circuit architecture.

Main Methods:

Analysis of gene circuit architectures.
Modeling of protein expression dynamics.
Investigation of noise-induced phenomena.
Exploration of bifurcation theory and phase-space topology.

Main Results:

Identified various gene circuit designs capable of producing excitable protein expression pulses.
Demonstrated that different types of excitable dynamics can emerge based on bifurcation structures.
Showed that a single gene circuit design can support multiple classes of excitable dynamics by altering system parameters.

Conclusions:

Gene circuit architecture is not solely deterministic of excitable dynamics.
System parameters and underlying bifurcation structures significantly influence the type of excitable dynamics observed.
Noise-driven excitable dynamics are a versatile phenomenon in cellular processes regulated by gene circuits.