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Cardiovascular mortality in men with erectile dysfunction: increased risk but not inevitable

Kew-Kim Chew1, Nicholas Gibson, Frank Sanfilippo

  • 1Keogh Institute for Medical Research, Nedlands, Perth, Western Australia 6009, Australia. kewkimchew@hotmail.com

The Journal of Sexual Medicine
|March 24, 2011
PubMed

Insights

Men with erectile dysfunction (ED) face a higher risk of cardiovascular (CV) death. However, oncological causes account for a similar proportion of deaths, often occurring sooner after ED onset.

Area of Science:

  • Cardiovascular health
  • Men's health
  • Epidemiology

Background:

  • The ultimate cause of death in men with erectile dysfunction (ED) remains unclear.
  • Cardiovascular (CV) disease is a significant concern in men with ED.

Purpose of the Study:

  • To investigate the causes of death in men diagnosed with ED.
  • To assess the risk of cardiovascular death among men with ED.

Main Methods:

  • Utilized statutory death registrations and hospital morbidity data for a linked-data study.
  • Compared CV death risk in men with ED against a reference male population.
  • Analyzed age-specific rates, mortality rate ratios (MRR), standardized mortality rate ratios (SMRR), and adjusted hazard ratios (HR).

Main Results:

  • Men with ED exhibited a higher risk of CV death (SMRR 2.2).
  • Pre-existing CV disease or prior hospital admissions for CV events increased CV mortality risk.
  • The risk of CV death was notably higher in the 40-69 age group (MRR 4.1).
  • Median time from ED manifestation to CV death was 10 years.

Conclusions:

  • Men with ED have an elevated risk of cardiovascular mortality.
  • Oncological causes represent a significant proportion of deaths in men with ED, comparable to CV causes.
  • Oncological deaths tend to occur earlier after the initial manifestation of ED compared to CV deaths.
Abstract

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