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Related Experiment Video

Updated: Jun 3, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Common genetic variants associated with open-angle glaucoma.

Wishal D Ramdas¹, Leonieke M E van Koolwijk, Hans G Lemij

¹Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.

Human Molecular Genetics

|March 24, 2011

Summary

This summary is machine-generated.

This study investigated genetic links to open-angle glaucoma, finding three common variants (CDKN2B, ATOH7, SIX1) significantly associated with the eye disorder. These findings offer new insights into glaucoma

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Last Updated: Jun 3, 2026

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Open-angle glaucoma is a leading cause of vision loss, characterized by optic disc pathology.
Genome-wide association studies have identified genetic loci linked to optic disc parameters like optic disc area and vertical cup-disc ratio (VCDR).

Purpose of the Study:

To investigate the association of previously identified genetic loci with open-angle glaucoma.
To determine the extent to which specific genetic loci influence glaucoma development.

Main Methods:

A meta-analysis was conducted using data from six independent studies, including a total of 3161 glaucoma cases and 42,837 controls.
Eight specific genetic loci (ATOH7, CDC7/TGFBR3, SALL1, CDKN2B, SIX1, SCYL1/LTBP3, CHEK2, DCLK1) were examined for their association with glaucoma.

Main Results:

Significant evidence of association with glaucoma was found for three loci: CDKN2B (P=1.41 × 10⁻⁸), ATOH7, and SIX1.
Borderline significant associations were observed for CDC7/TGFBR3 and SALL1 (P=0.04).

Conclusions:

Three common genetic variants (CDKN2B, ATOH7, SIX1) are significantly associated with open-angle glaucoma.
These findings contribute to understanding the pathophysiological pathways in glaucoma, particularly those related to optic nerve development.