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Solution-phase synthesis of alpha-rat atrial natriuretic peptide (alpha-rANP)
M Yoshida1, M Shimokura, Y Fujiwara
1Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
Chemical & Pharmaceutical Bulletin
|April 1, 1990
Abstract:
alpha-Rat atrial natriuretic peptide (alpha-rANP) was synthesized by assembling five peptide fragments in solution, followed by HF-dimethylselenide-m-cresol deprotection and subsequent air-oxidation. Synthetic alpha-rANP exhibited more potent diuretic and natriuretic activity in rats than synthetic alpha-hANP.