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Relative kidney hyperfiltration in primary aldosteronism: a meta-analysis
Chin-Chi Kuo1, Vin-Cent Wu, Ching-Wei Tsai
1Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan.
Journal of the Renin-Angiotensin-Aldosterone System : JRAAS
|March 26, 2011
Summary
This meta-analysis confirms relative kidney hyperfiltration is a key feature of primary aldosteronism (PA), independent of hypertension. This finding highlights potential occult renal damage in PA patients.
Area of Science:
- Nephrology
- Endocrinology
- Clinical Research
Background:
- Primary aldosteronism (PA) is associated with hyperfiltration, but previous studies yielded conflicting results.
- The phenomenon of hyperfiltration in PA was first observed in 1996.
- Conflicting results necessitate further investigation into relative kidney hyperfiltration in PA.
Purpose of the Study:
- To determine the development of relative hyperfiltration in primary aldosteronism (PA).
- To perform a meta-analysis to synthesize existing evidence on hyperfiltration in PA.
Main Methods:
- Searched MEDLINE, EMBASE, and CENTRAL databases up to July 2009.
- Reviewed reference sections of relevant articles, meta-analyses, and reviews.
- Included hypertensive patients for controlled data and extracted data independently.
Main Results:
- Seven studies were included in the meta-analysis.
- Strong evidence supports relative kidney hyperfiltration in PA (SMD 0.13, 95% CI 0.03-0.22).
- Significant heterogeneity was observed (p < 0.0001), with mean age as a factor.
Conclusions:
- Relative kidney hyperfiltration is a hallmark of PA, exceeding the impact of hypertension.
- Clinicians should consider the potential for occult renal damage in PA patients.
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