In vivo investigation of extracellular ubiquitin effect on liver histoarchitectonics

Ubiquitin is a small regulatory protein of living cells. It affects almost all cellular processes. Investigation of ubiquitin is very important for discovering the new therapeutics for different heavy human diseases. The main goal of presented work was to reveal effect of extracellular ubiquitin on liver histoarchitectonic of mature and immature white rats. The obtained data indicate the inefficiency of used doses--200 μg/ml and 500 μg/ml--of extracellular ubiquitin single and multiple in vivo injections to evident changes of histoarchitectonics of immature and mature white rat liver. Further investigation of in vivo injection effects on histoarchitectonics of intact and damaged liver and hepatocyte cell cycle regulation by immunological assays seems to be actual and interesting.